It is recommended to add antioxidants at the time of production of the raw material. Quality: Orange leaf bigarade may be adulterated with the cheaper Paraguayan oil, which itself is frequently adulterated (Kubeczka 2002). Of 18,747 dermatitis patients, 1,781 had contact dermatitis and one (0.005% of dermatitis patients and 0.06% of contact dermatitis patients) was allergic to linalool. In a modified Draize procedure on guinea pigs, linalool was not sensitizing when used at 10% in the challenge phase (Sharp 1978). Hypersalivation, muscle tremors, ataxia, lateral recumbency, coma, and death were noted experimentally in three cats following use of the dip according to label directions. Similarly, an aqueous suspension of carrot seed oil, injected iv into dogs, produced dose-dependent falls in BP (Bhargava et al 1967). Pertinent to this, the local anesthetic effects of linalool are equal to those of procaine and menthol (Ghelardini, Galeotti, Salvatore, & Mazzanti, 1999; Re et al., 2000). This would not dramatically increase the time taken to process small batches samples, but might be more problematic for the analysis of large numbers of samples. Patch testing with 5% linalool elicited no reactions in 99 patients with non-cosmetic dermatitis, nor in 60 patients with cosmetic dermatitis (Itoh et al 1986, 1988). The presence of furanoid linalool oxide (71) as shown in Scheme 17 and 2-methyl-2-vinyltetrahydrofuran-5-one (72) as the unsaturated lactone in the fermentation medium suggested another mode of utilization of linalool (63). Of the remaining linalool, 0.5% was found in the liver, 0.6% in the gut, 0.8% in the skin and 1.2% in the skeletal muscle (Parke et al 1974b). Planta. Headspace data analysis (Fig. Linalool (LN) is an acyclic monoterpene alcohol that exerted its antiproliferative activity against various cancer cells via the mevalonate pathway [31]. It is also widely used as a single compound in fragrances. Thyme at top of mountain: high in linalool, better quality safe oil from stronger plants. Adverse skin reactions: Tested at 20% on two separate panels of 25 healthy human volunteers linalool was not irritating (Fujii et al 1972; Opdyke 1975 p. 827–832). Degradative metabolic pathway of (+)-linalool (63) by Pseudomonas pseudomallei. Thyme at very bottom of mountain: oil contains significant amount of phenol. Thyme near bottom of mountain: higher in geraniol, intermediate composition. Rat urinary metabolites of linalool were also non-mutagenic (Rockwell & Raw 1979). Carcinogenic/anticarcinogenic potential: A single application of DMBA in 0.2 mL acetone was made to the clipped skin of albino mice. Since there was some maternal increase in relative body weight and feed consumption in the high dose group, the NOAEL for maternal toxicity was 500 mg/kg/day (Politano et al 2008). (S)-(+)-Linalool (63) makes up 60–70% of coriander oil. Both enantiomeric forms are found in nature: (S)-linalool is found, for example, as a major constituent of the essential oils of coriander (Coriandrum sativum L.), cymbopogon (Cymbopogon martini var. One survey found it in 61% (36 of 59) of household products (Rastogi et al 2001). Mutagenicity and genotoxicity: Linalool was not mutagenic in Ames tests with and without S9 (Rockwell & Raw 1979; Eder et al 1980, 1982; Ishidate et al 1984; Heck et al 1989; Di Sotto et al 2008), nor was it mutagenic in CA tests (Ishidate et al 1984; Letizia et al 2003a), or in a mouse micronucleus assay (Letizia et al 2003a). Linalool in ambient air decreased mouse motility 73%, confirming its potent sedative effects (Buchbauer et al., 1993). The pinane and bornane monoterpenes undergo bicyclization at opposing ends of the remaining double bond of the α-terpinyl cation (31) to generate the favored tertiary cation (pinyl cation (39)) or a less-favored, anti-Markovnikov secondary cation (bornyl cation (40)). The biotransformation of linalool (63) by B. cinerea was carried out and transformation products such as (E)- (64a) and (Z)-2,6-dimethyl-2,7-octadiene-1,6-diol (64b), trans- (71a) and cis-furanoid linalool oxide (71b) (Scheme 18), trans- (82a) and cis-pyranoid linalool oxide (82b) (Scheme 19) and their acetates (82a-Ac and 82b-Ac), 3,9-epoxy-p-menth-1-ene (81), and 2-methyl-2-vinyltetrahydrofuran-5-one (72) (unsaturated lactone) (Scheme 20) were identified.44 Quantitative analysis, however, showed that linalool (63) was predominantly (90%) metabolized to (E)-2,6-dimethyl-2,7-octadiene-1,6-diol (64a) by B. cinerea. Linalool production in tobacco leaves expressing ApLS1 in the absence of P19 was only observed at very low levels (∼ 0.03 μg gFW− 1 h− 1) 3-day postinfiltration. Acute dermal LD50 in rabbits 5.61 g/kg (Opdyke 1975 p. 827–832). It possesses enzyme inducing and sedative properties. They differ from each other by their chemotype (biochemical composition). After one hour of inhaling 5 mg/L linalool, serum levels in mice were 7–9 ng/mL (Jirovetz et al 1991). These facts showed that G. cingulata recognized the absolute configuration of the secondary hydroxyl group at C-3. The amount of linalool is expressed as μg (g fresh weight)− 1 h−1(gFW h− 1) and was quantified against an authentic external linalool standard. Sol A. It is notable that the majority of these reactions were + and the rest were ++; no +++ reactions were seen (Matura et al 2005). Linalool in essential oils. Linalool showed significant activity against histiocytic lymphoma U937 cells and Burkitt lymphoma P3HR1 cells (human cell lines) with IC50 values of 3.51 and 4.21 μg/mL, respectively. Intravenous 1,8-cineole was dose-dependently hypotensive in normotensive rats at 0.3–10 mg/kg, and decreased heart rate at the highest dose (Lahlou et al 2002a). Postinfiltration solvent extraction of detached leaves was carried out at different intervals over a 14-day period and volatiles analyzed by GC–MS (A–E). The other compounds were only found as by-products in minor concentrations. Please enable it to take advantage of the complete set of features! There were no reactions to 30% linalool in 179 dermatitis patients suspected of allergy to cosmetics (De Groot et al 1985). Scheme 24. Of 1,200 dermatitis patients patch tested, there were no irritant reactions and no allergic reactions to 5% linalool (Santucci et al 1987). The oxidation data has been used by the SCCNFP to justify its opinion that linalool should be listed as an allergen (SCCNFP 2003d). In male and female mice given 24 ip injections of linalool in tricaprylin in a total dose of 0.6 or 3.0 g/kg over 24 weeks the incidence of primary lung tumors was no higher than in the control group (Stoner et al 1973). USA.gov. Tadtong S, Suppawat S, Tintawee A, Saramas P, Jareonvong S, Hongratanaworakit T. Nikolić MM, Jovanović KK, Marković TL, Marković DL, Gligorijević NN, Radulović SS, Kostić M, Glamočlija JM, Soković MD. Madyastha et al.16 isolated a soil Pseudomonad, Pseudomonas incognita, by an enrichment culture technique with linalool as the sole carbon source. Since no linalool was detected at the latter points of the time course, this suggests that complete gene silencing of ApLS1 has occurred. Epub 2017 Jan 9. Robert Tisserand, Rodney Young PhD, in Essential Oil Safety (Second Edition), 2014, Source: Flowering leaves and terminal branches. Although linalool was produced in tobacco leaves expressing ApLS1 in the absence of P19 (Fig. In the biotransformation of racemic cis-linalool oxide-pyranoid, (+)-(3R,6R)-cis-pyranoid linalool oxide (82a and 82a′) was converted to (3R,6R)-pyranoid-cis-linalool oxide-3-malonate (83). National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Although this oil is not commercially available, it is interesting to note that it contains 16.8% 1,8-cineole, as well as 12.3% bicyclogermacrene and 11.3% α-pinene (Menezes et al 2007). In traditional aromatherapy, linalool is the likely suspect in the remarkable therapeutic capabilities of lavender EO to alleviate skin burns without scarring (Gattefosse, 1993). 2018 May 10;10(5):515. doi: 10.3390/polym10050515. Thyme near bottom of mountain: higher in geraniol, intermediate composition. The biotransformation was also carried out with growing surface cultures. Acute toxicity from high doses presents as ataxia and narcosis (Powers & Beasley 1985). The biodegradation of (+)-linalool (63) by Pseudomonas pseudomallei (strain A), which grows on linalool as the sole carbon source, was described in 1973 (Scheme 16).42.

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