[7] Sodium benzoate is also allowed as an animal food additive at up to 0.1%, per the Association of American Feed Control Officials. Revised April 2011. Sodium benzoate has been replaced by potassium sorbate in the majority of soft drinks in the United Kingdom.[9]. Recent research shows that sodium benzoate may be beneficial as an add-on therapy (1 gram/day) in schizophrenia. Sodium benzoate, along with phenylbutyrate, is used to treat hyperammonemia. [22][23], Cats have a significantly lower tolerance against benzoic acid and its salts than rats and mice. Sodium benzoate is an antimicrobial preservative and flavoring agent used in the food industry and a tablet and capsule lubricant used in the pharmaceutical manufacturing industry. [4] FDA believes that the results of the surveys indicate that the levels of benzene found in soft drinks do not pose a safety concern. . It is most widely used in acidic foods such as salad dressings (i.e. We comply with the HONcode standard for trustworthy health information -, Sulfamethoxazole and Trimethoprim 800 mg / 160 mg. [21] The International Programme on Chemical Safety found no adverse effects in humans at doses of 647–825 mg/kg of body weight per day. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Overview of pharmaceutical excipients used in tablets and capsules. Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice. Accessed August 4, 2009. http://www.fda.gov/Food/FoodSafety/FoodContaminantsAdulteration/ChemicalContaminants/Benzene/ucm055815.htm and http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2006/ucm108636.htm. The mechanism starts with the absorption of benzoic acid into the cell. Food Contaminants and Adulteration. Many other influences are at work but this at least is one a child can avoid. EC number: 208-534-8 | CAS number: 532-32-1. "[30], InChI=1S/C7H6O2.Na/c8-7(9)6-4-2-1-3-5-6;/h1-5H,(H,8,9);/q;+1/p-1, InChI=1/C7H6O2.Na/c8-7(9)6-4-2-1-3-5-6;/h1-5H,(H,8,9);/q;+1/p-1, Except where otherwise noted, data are given for materials in their, "International Programme on Chemical Safety", "Skin Deep® Cosmetics Database | Environmental Working Group", "Suggested guidelines for the diagnosis and management of urea cycle disorders", Add-on Treatment of Benzoate for Schizophrenia A Randomized, Double-blind, Placebo-Controlled Trial of d-Amino Acid Oxidase Inhibitor, Mental Health Research Institute Staff Publications, "Cinnamon May Help Halt Parkinson's Disease Progression - News Releases - Rush University Medical Center", mayoclinic.org, Caffeine And Sodium Benzoate (Injection Route), ebi.ac.uk, CHEBI:32140 - sodium caffeine benzoate, "Studies on the mechanism of the antifungal action of benzoate", "CFR - Code of Federal Regulations Title 21", "Concise International Chemical Assessment Document 26: Benzoic acid and sodium benzoate", "Final Report on the Safety Assessment of Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate", "Data on Benzene in Soft Drinks and Other Beverages", United States Food and Drug Administration, Food Standards Agency issues revised advice on certain artificial colours, Agency revises advice on certain artificial colours, The United States Pharmacopeial Convention, International Programme on Chemical Safety - Benzoic Acid and Sodium Benzoate report, "Dose-dependent pharmacokinetics of benzoic acid following oral administration of sodium benzoate to humans", 2008 United States salmonellosis outbreak, 2017–18 South African listeriosis outbreak, 2018 Australian rockmelon listeriosis outbreak, Spanish Agency for Food Safety and Nutrition, https://en.wikipedia.org/w/index.php?title=Sodium_benzoate&oldid=982153065, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License, This page was last edited on 6 October 2020, at 13:19. In 2006, the Food and Drug Administration tested 100 beverages available in the United States that contained both ascorbic acid and benzoate. [10][11] This leads to excretion of these amino acids and a decrease in ammonia levels. It is a widely used food pickling agent, with an E number of E211. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Sodium benzoate EC Number: 208-534-8 EC Name: Sodium benzoate CAS Number: 532-32-1 Molecular formula: C7H6O2.Na IUPAC Name: sodium benzoate [8] It can be produced by reacting sodium hydroxide with benzoic acid. Those products that were above the upper limit have since been reformulated. Available for Android and iOS devices. Concentration as a food preservative is limited by the FDA in the U.S. to 0.1% by weight. [1] Dave RH. Sodium benzoate is synthesized by combining benzoic acid with sodium hydroxide. . Medically reviewed by Drugs.com. Through this therapy the severe symptoms of NKH like seizures and lethargy can be alleviated. The results were inconsistent regarding sodium benzoate, so the FSA recommended further study. Toxicity of any type would not typically occur until a human ate a diet that contained ninety times the amount specified by the FDA. Accessed 8/16/2012. Sodium benzoate has a chemical formula of C7H5NaO2. While sodium benzoate does not occur naturally, benzoic acid and its esters are found in many foods. United States Food and Drug Administration. It is used to lower the high glycine levels caused by this disease, as benzoate is able to bind glycine to form hippuric acid, which can be excreted renally. Sodium benzoate is a substance which has the chemical formula C6H5COONa. acetic acid in vinegar), carbonated drinks (carbonic acid), jams and fruit juices (citric acid), pickles (acetic acid), condiments, and frogurt toppings. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If the intracellular pH falls to 5 or lower, the anaerobic fermentation of glucose through phosphofructokinase decreases sharply,[20] which inhibits the growth and survival of microorganisms that cause food spoilage. [23] The metabolic pathway for this begins with the conversion of benzoate by butyrate-CoA ligase into an intermediate product, benzoyl-CoA,[25] which is then metabolized by glycine N-acyltransferase into hippuric acid.[26].


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